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Medical News Today: Lupus: a serious disease we know little about

What do you know about lupus? Based on the results of a survey from the Lupus Foundation of America, it is likely to be very little; around 72% of Americans aged 18-34 have either not heard of the disease or know nothing about it other than the name, despite this age group being at greatest risk for the condition.
Lupus is a chronic autoimmune disease in which the immune system produces autoantibodies that attack healthy cells and tissues.

Chances are you may have started to hear more about lupus of late, after 23-year-old singer Selena Gomez announced she had been diagnosed with the condition in her late teens and underwent treatment for the disease last year.

“I was diagnosed with lupus, and I’ve been through chemotherapy. That’s what my break was really about. I could’ve had a stroke,” she told Billboard magazine earlier this month.

Gomez is just one of the 1.5 million Americans that are estimated to have some form of lupus, and each year, more than 16,000 new cases are diagnosed in the US.

Around 90% of those diagnosed with lupus are women, with black women around three times more likely to develop the condition than white women.

But what exactly is lupus? What are its symptoms and complications? And why is it that we know so little about the disease? We investigate.

The causes, symptoms and complications of lupus

Lupus is a chronic autoimmune disease in which the immune system produces autoantibodies that attack healthy cells and tissues, including those of the skin, joints, heart, lung, kidneys and brain.

While the exact cause of lupus is unclear, the disease can be triggered by certain environmental factors, such as exposure to sunlight, stress and smoking. Pregnancy is also a common trigger for the condition among women.

Since lupus is most common among women during childbearing years, researchers speculate that the female hormone estrogen may play a role in disease development.

SLE is the most common form of lupus, which can affect any part of the body.

In addition, it is suspected that lupus development may be influenced by certain genes, though researchers believe it is unlikely that genes alone trigger the disease, but that it is rather a combination of factors.

There are many different forms of lupus. Systemic lupus erythematosus (SLE) is the most common, accounting for around 70% of all cases. In SLE, any part of the body can be affected, though around 80% of cases involve the skin.

Symptoms of SLE include chest pain, shortness of breath, muscle pain, fatigue, fever, hair loss, mouth sores, light sensitivity, anemia and skin rash – most commonly a butterfly-shaped rash that spans the cheeks and bridge of the nose.

Other forms of lupus include cutaneous lupus erythematosus, which is limited to the skin, and drug-induced lupus erythematosus, which can be triggered by certain prescription drugs, including hydralazine and procainamide. Symptoms of drug-induced lupus are similar to those of SLE, though the major organs are rarely affected.

The majority of people with lupus often experience “flare-ups,” in which symptoms worsen for a period of time before improving or disappearing completely.

Complications from lupus depend on what part of the body is affected. Individuals with inflammation in the brain, for example, may experience headaches, memory problems and confusion and are at greater risk for stroke.

Lupus can cause severe kidney damage; around 40% of people with lupus experience kidney complications and it is one of the leading causes of death among people with the condition.

Inflammation of the blood vessels – known as vasculitis – or inflammation of the heart also raises the risk for heart attack and cardiovascular disease for people who have lupus; people with lupus are twice as likely to develop cardiovascular disease than those without the condition.

Individuals with lupus are also more susceptible to infection because the disease and its treatments can weaken the immune system. Respiratory tract infections, urinary tract infections, salmonella, herpes, shingles and yeast infections are among the most common.

Lupus: ‘the great imitator’

Lupus is often deemed the “great imitator” because the symptoms of the disease are so similar to other conditions, meaning the disease is often mistaken for other illnesses by both patients and doctors.

According to the 2014 “UNVEIL” survey, conducted by Lupus Foundation of America and Eli Lilly, it takes an average of 6 years for someone with lupus to receive a diagnosis from when symptoms first present themselves.

In addition, the survey revealed that 66% of people with lupus reported being incorrectly diagnosed, while more than half of these participants reported seeing at least four health care providers before being accurately diagnosed.

What is more, each patient with lupus will present very different symptoms, making the condition even trickier to diagnose.

Dr. Susan Manzi, co-director of the Lupus Center of Excellence in Pittsburgh, PA, explains:

“One of the greatest mysteries of lupus is that it affects different people in different ways – no two cases are exactly alike. This disparity makes lupus one of the most difficult diseases for physicians to diagnose, treat, and manage.”

What makes diagnosis harder is that there is no single test to identify the disease. Lupus is commonly identified through a combination of blood and urine tests, physical examination and biopsies.

Blood tests may be conducted to determine whether a patient has a low white blood cell or platelet count, or whether they have low hemoglobin levels – a protein found in red blood cells – all of which can be indicators of lupus.

The antinuclear antibody (ANA) test is another way in which doctors may diagnose lupus. The majority of people with lupus test positive for ANA, though a positive result is not a definitive indicator of the condition; positive ANA tests can occur in around 5-10% of healthy women.

Urine tests may be carried out in order to identify an increase in protein levels or red blood cells, which can be a sign that lupus is affecting the kidneys

A doctor may also perform a skin or kidney biopsy in order to diagnose lupus. The samples are viewed under a microscope and assessed for changes that may indicate the presence of the disease.

On the next page we discuss the treatment options for lupus and the challenges of living with the disease.



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